Molecular shielding of porcine islets by tissue-adhesive chitosan-catechol for enhancement of in-vitro stability

Jee-Heon Jeong; Yoon-Joo Woo; Mihyun Lee; Muhammad R. Haque; Cheol-Hee Ahn; Haeshin Lee; Youngro Byun

Journal of Industrial and Engineering Chemistry, Vol.57, 330-338, January, 2018

DOI10.1016/j.jiec.2017.08.040 Export Citation

Molecular shielding of porcine islets by tissue-adhesive chitosan-catechol for enhancement of in-vitro stability

Jee-Heon Jeong¹, Yoon-Joo Woo², Mihyun Lee³, Muhammad R. Haque⁴, Cheol-Hee Ahn⁵, Haeshin Lee^{3, 6}, and Youngro Byun^{2, 4, †}

¹College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Republic of Korea
²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, Republic of Korea
³Department of Chemistry, Korea Advanced Institute of Science and Technology, 291 Daehak-ro Yuseong-gu, Daejeon 305-701, Republic of Korea
⁴Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea
⁵Engineering Research Institute, Department of Materials Science and Engineering, Seoul National University, Seoul 151-742, Republic of Korea
⁶KAIST Institute for NanoCentury (KINC) and BioCentury (KIB), Korea Advanced Institute of Science and Technology, 291 Daehak-ro Yuseong-gu, Daejeon 305-712, Republic of Korea

E-mail:

Porcine islets are an alternative cell source for cell replacement therapy in diabetes. However, porcine islets are very fragile, and isolated islets are easily damaged during culture. Therefore, the purpose of this study was to incorporate a tissue-adhesive chitosan derivative on the surface of porcine islets to prevent the dissociation of porcine islet clusters into single cells. Chitosan-catechol was evenly covered on the surface of islets without any toxicity. In addition, the tissue-adhesive chitosan catechol was effective in preventing cell dissociation. Therefore, tissue adhesive chitosan-catechol conjugation onto the porcine islet surface is a promising technique to stabilize islets after isolation.

Keywords:Porcine islets;Chitosan-catechol;Islet stability;Surface modification;Carbohydrate

[References]

Brandhorst H, Duan Y, Iken M, Bretzel RG, Brandhorst D, Transplant. Proc., 37, 3519 (2005)
Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, et al., N. Engl. J. Med., 355, 1318 (2006)
Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV, N. Engl. J. Med., 343, 230 (2000)
Ricordi C, Diabetes, 52, 1595 (2003)
Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, Kneteman NM, Lakey JR, Shapiro AM, Diabetes, 54, 2060 (2005)
Street CN, Sipione S, Helms L, Binette T, Rajotte RV, Bleackley RC, Korbutt GS, Int. J. Biochem. Cell Biol., 36, 667 (2004)
Jeong JH, Yook S, Jung Y, Im BH, Lee M, Ahn CH, Lee DY, Byun Y, J. Control. Release, 159, 368 (2012)
Sharma A, Sorenby A, Wernerson A, Efendic S, Kumagai-Braesch M, Tibell A, Diabetologia, 49, 1247 (2006)
Elliott RB, Escobar L, Tan PL, Muzina M, Zwain S, Buchanan C, Xenotransplantation, 14, 157 (2007)
Orive G, Hernandez RM, Gascon AR, Calafiore R, Chang TM, De Vos P, Hortelano G, Hunkeler D, Lacik I, Shapiro AM, Pedraz JL, Nat. Med., 9, 104 (2003)
Hering BJ, Wijkstrom M, Graham ML, Hardstedt M, Aasheim TC, Jie T, Ansite JD, Nakano M, Cheng J, Li W, Moran K, Christians U, Finnegan C, Mills CD, Sutherland DE, Bansal-Pakala P, Murtaugh MP, Kirchhof N, Schuurman HJ, Nat. Med., 12, 301 (2006)
Jung KC, Park CG, Jeon YK, Park HJ, Ban YL, Min HS, Kim EJ, Kim JH, Kang BH, Park SP, Bae Y, Yoon IH, Kim YH, Lee JI, Kim JS, Shin JS, Yang J, Kim SJ, Rostlund E, Muller WA, Park SH, J. Exp. Med., 208, 2477 (2011)
Hering BJ, Cooper DK, Cozzi E, Schuurman HJ, Korbutt GS, Denner J, O'Connell PJ, Vanderpool HY, Pierson 3rd RN, Xenotransplantation, 16, 196 (2009)
Chen Y, Stewart JM, Gunthart M, Hawthorne WJ, Salvaris EJ, O’Connell PJ, Nottle MB, d’Apice AJ, Cowan PJ, Kearns-Jonker M, Xenotransplantation, 21, 244 (2014)
Stendahl JC, Kaufman DB, Stupp SI, Cell Transplant., 18, 1 (2009)
Paraskevas S, Maysinger D, Wang R, Duguid TP, Rosenberg L, Pancreas, 20, 270 (2000)
Ricordi C, Socci C, Davalli AM, Staudacher C, Baro P, Vertova A, Sassi I, Gavazzi F, Pozza G, Di Carlo V, Surgery, 107, 688 (1990)
van Deijnen JH, Hulstaert CE, Wolters GH, van Schilfgaarde R, Cell Tissue Res., 267, 139 (1992)
Jeong JH, Yook S, Hwang JW, Jung MJ, Moon HT, Lee DY, Byun Y, Transplant. Proc., 45, 585 (2013)
Im BH, Jeong JH, Haque MR, Lee DY, Ahn CH, Kim JE, Byun Y, Biomaterials, 34, 2098 (2013)
Jung YS, Jeong JH, Yook S, Im BH, Seo J, Hong SW, Park JB, Yang VC, Lee DY, Byun Y, Biomaterials, 33, 295 (2012)
Jeong JH, Hong SW, Hong S, Yook S, Jung Y, Park JB, Khue CD, Im BH, Seo J, Lee H, Ahn CH, Lee DY, Byun Y, Biomaterials, 32, 7961 (2011)
Kean T, Thanou M, Adv. Drug Deliv. Rev., 62, 3 (2010)
Dufes C, Muller JM, Couet W, Olivier JC, Uchegbu IF, Schatzlein AG, Pharm. Res., 21, 101 (2004)
Li P, Poon YF, Li WF, Zhu HY, Yeap SH, Cao Y, Qi XB, Zhou CC, Lamrani M, Beuerman RW, Kang ET, Mu YG, Li CM, Chang MW, Leong SSJ, Chan-Park MB, Nat. Mater., 10(2), 149 (2011)
Zaharoff DA, Rogers CJ, Hance KW, Schlom J, Greiner JW, Vaccine, 25, 2085 (2007)
Yang SH, Lee YS, Lin FH, Yang JM, Chen KS, J. Biomed. Mater. Res. B Appl. Biomater., 83, 304 (2007)
Rabea EI, Badawy MET, Stevens CV, Smagghe G, Steurbaut W, Biomacromolecules, 4(6), 1457 (2003)
Ryu JH, Lee Y, Kong WH, Kim TG, Park TG, Lee H, Biomacromolecules, 12(7), 2653 (2011)
Lee H, Scherer NF, Messersmith PB, Proc. Natl. Acad. Sci. U. S. A., 103, 12999 (2006)
Guvendiren M, Brass DA, Messersmith PB, Shull KR, J. Adhes., 85(9), 631 (2009)
Wang RN, Paraskevas S, Rosenberg L, J. Histochem. Cytochem., 47, 499 (1999)
Illum L, Pharm. Res., 15, 1326 (1998)
Ryu JH, Lee Y, Do MJ, Jo SD, Kim JS, Kim BS, Im GI, Park TG, Lee H, Acta Biomater., 10, 224 (2014)
Rayat GR, Rajotte RV, Korbutt GS, Ann. N. Y. Acad. Sci., 875, 175 (1999)
Konstantinova I, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S, Lammert E, Cell, 129, 359 (2007)

[Referenced By]

[1] Brandhorst H, Duan Y, Iken M, Bretzel RG, Brandhorst D, Transplant. Proc., 37, 3519 (2005)

[2] Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, et al., N. Engl. J. Med., 355, 1318 (2006)

[3] Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV, N. Engl. J. Med., 343, 230 (2000)

[4] Ricordi C, Diabetes, 52, 1595 (2003)

[5] Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, Kneteman NM, Lakey JR, Shapiro AM, Diabetes, 54, 2060 (2005)

[6] Street CN, Sipione S, Helms L, Binette T, Rajotte RV, Bleackley RC, Korbutt GS, Int. J. Biochem. Cell Biol., 36, 667 (2004)

[7] Jeong JH, Yook S, Jung Y, Im BH, Lee M, Ahn CH, Lee DY, Byun Y, J. Control. Release, 159, 368 (2012)

[8] Sharma A, Sorenby A, Wernerson A, Efendic S, Kumagai-Braesch M, Tibell A, Diabetologia, 49, 1247 (2006)

[9] Elliott RB, Escobar L, Tan PL, Muzina M, Zwain S, Buchanan C, Xenotransplantation, 14, 157 (2007)

[10] Orive G, Hernandez RM, Gascon AR, Calafiore R, Chang TM, De Vos P, Hortelano G, Hunkeler D, Lacik I, Shapiro AM, Pedraz JL, Nat. Med., 9, 104 (2003)

[11] Hering BJ, Wijkstrom M, Graham ML, Hardstedt M, Aasheim TC, Jie T, Ansite JD, Nakano M, Cheng J, Li W, Moran K, Christians U, Finnegan C, Mills CD, Sutherland DE, Bansal-Pakala P, Murtaugh MP, Kirchhof N, Schuurman HJ, Nat. Med., 12, 301 (2006)

[12] Jung KC, Park CG, Jeon YK, Park HJ, Ban YL, Min HS, Kim EJ, Kim JH, Kang BH, Park SP, Bae Y, Yoon IH, Kim YH, Lee JI, Kim JS, Shin JS, Yang J, Kim SJ, Rostlund E, Muller WA, Park SH, J. Exp. Med., 208, 2477 (2011)

[13] Hering BJ, Cooper DK, Cozzi E, Schuurman HJ, Korbutt GS, Denner J, O'Connell PJ, Vanderpool HY, Pierson 3rd RN, Xenotransplantation, 16, 196 (2009)

[14] Chen Y, Stewart JM, Gunthart M, Hawthorne WJ, Salvaris EJ, O’Connell PJ, Nottle MB, d’Apice AJ, Cowan PJ, Kearns-Jonker M, Xenotransplantation, 21, 244 (2014)

[15] Stendahl JC, Kaufman DB, Stupp SI, Cell Transplant., 18, 1 (2009)

[16] Paraskevas S, Maysinger D, Wang R, Duguid TP, Rosenberg L, Pancreas, 20, 270 (2000)

[17] Ricordi C, Socci C, Davalli AM, Staudacher C, Baro P, Vertova A, Sassi I, Gavazzi F, Pozza G, Di Carlo V, Surgery, 107, 688 (1990)

[18] van Deijnen JH, Hulstaert CE, Wolters GH, van Schilfgaarde R, Cell Tissue Res., 267, 139 (1992)

[19] Jeong JH, Yook S, Hwang JW, Jung MJ, Moon HT, Lee DY, Byun Y, Transplant. Proc., 45, 585 (2013)

[20] Im BH, Jeong JH, Haque MR, Lee DY, Ahn CH, Kim JE, Byun Y, Biomaterials, 34, 2098 (2013)

[21] Jung YS, Jeong JH, Yook S, Im BH, Seo J, Hong SW, Park JB, Yang VC, Lee DY, Byun Y, Biomaterials, 33, 295 (2012)

[22] Jeong JH, Hong SW, Hong S, Yook S, Jung Y, Park JB, Khue CD, Im BH, Seo J, Lee H, Ahn CH, Lee DY, Byun Y, Biomaterials, 32, 7961 (2011)

[23] Kean T, Thanou M, Adv. Drug Deliv. Rev., 62, 3 (2010)

[24] Dufes C, Muller JM, Couet W, Olivier JC, Uchegbu IF, Schatzlein AG, Pharm. Res., 21, 101 (2004)

[25] Li P, Poon YF, Li WF, Zhu HY, Yeap SH, Cao Y, Qi XB, Zhou CC, Lamrani M, Beuerman RW, Kang ET, Mu YG, Li CM, Chang MW, Leong SSJ, Chan-Park MB, Nat. Mater., 10(2), 149 (2011)

[26] Zaharoff DA, Rogers CJ, Hance KW, Schlom J, Greiner JW, Vaccine, 25, 2085 (2007)

[27] Yang SH, Lee YS, Lin FH, Yang JM, Chen KS, J. Biomed. Mater. Res. B Appl. Biomater., 83, 304 (2007)

[28] Rabea EI, Badawy MET, Stevens CV, Smagghe G, Steurbaut W, Biomacromolecules, 4(6), 1457 (2003)

[29] Ryu JH, Lee Y, Kong WH, Kim TG, Park TG, Lee H, Biomacromolecules, 12(7), 2653 (2011)

[30] Lee H, Scherer NF, Messersmith PB, Proc. Natl. Acad. Sci. U. S. A., 103, 12999 (2006)

[31] Guvendiren M, Brass DA, Messersmith PB, Shull KR, J. Adhes., 85(9), 631 (2009)

[32] Wang RN, Paraskevas S, Rosenberg L, J. Histochem. Cytochem., 47, 499 (1999)

[33] Illum L, Pharm. Res., 15, 1326 (1998)

[34] Ryu JH, Lee Y, Do MJ, Jo SD, Kim JS, Kim BS, Im GI, Park TG, Lee H, Acta Biomater., 10, 224 (2014)

[35] Rayat GR, Rajotte RV, Korbutt GS, Ann. N. Y. Acad. Sci., 875, 175 (1999)

[36] Konstantinova I, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S, Lammert E, Cell, 129, 359 (2007)