화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.28, No.1, 9-14, January, 2020
DOI10.1007/s13233-020-8004-5  Export Citation
Poly-l-lactide Polymer-Based Triple Drug-Eluting Stent with Abciximab, Alpha-Lipoic Acid and Sirolimus in Porcine Coronary Restenosis Model
Jun-Kyu Park1, Sung Soo Kim2, Hyun Kuk Kim2, Jae-Woon Nah3, Han Byul Kim4, In Ho Bae4, 5, Dae Sung Park4, 5, Jae Won Shim4, 5, Min Young Lee6, Joong Sun Kim7, Bon-Sang Koo8, Kang-Jin Jeong8, Yeong Bae Jin8, Sun-Uk Kim8, Sang-Rae Lee8, Joo-Young Na9, Doo Sun Sim3, 10, Young Joon Hong3, Kyung Seob Lim8, †, and Myung Ho Jeong3, 4, †
  • 1CGBio Co. Ltd, Jangseong 14722, Korea
  • 2Department of Internal Medicine and Cardiovascular Center, Chosun University Hospital, University of Chosun College of Medicine, Gwangju 61453, Korea
  • 3Department of Polymer Science and Engineering, Sunchon National University, Suncheon 57922, Korea
  • 4Cardiovascular Research Center, Chonnam National University Hospital, Gwangju 61469, Korea
  • 5Korea Cardiovascular Stent Research Institute, Jangsung 57248, Korea
  • 6College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea
  • 7Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
  • 8Futuristic Animal Resource and Research Center & National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang 28116, Chungbuk, Korea
  • 9Biomedical Research Institute, Chonnam National University Hospital, Gwangju 61469, Korea
  • 10Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju 61469, Korea
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This study evaluated the effect of a novel triple drug-eluting stent containing antithrombotic abciximab, antioxidative alpha-lipoic acid (ALA), and antiproliferative sirolimus in a porcine model. The coronary arteries of pigs were randomized into three groups: triple drug-eluting stent (TES; n=10), sirolimus-eluting stent (SES; n=10), and bare metal stent (BMS; n=10). At 28 days after stent implantation, a histopathologic analysis was performed. There were no significant differences in the injury score. There were significant differences in the neointimal area (2.3±0.6 mm2 in TES vs. 2.5±0.88 mm2 in SES vs. 3.3±0.58 mm2 in BMS, p<0.0001), percent area of stenosis (37.1±9.26% in TES vs. 46.1±15.9% in SES vs. 66.2±10.12% in BMS, p<0.0001), inflammation score (1.0 [range, 0.0-1.0] in TES vs. 1.5 [range, 1.0-2.0] in SES vs. 1.0 [range, 1.0-2.0] in BMS, p<0.05), and fibrin score (2.0 [range, 1.0-2.0] in TES vs. 2.0 [range, 1.0-2.5] in SES vs. 0.0 [range, 0.0-1.0] in BMS, p<0.0001) among the three groups. The occlusion rates using micro-computed tomography showed similar restenosis rates based on histologic analysis (35.4±8.39% in TES vs. 43.4±10.12% in SES vs. 71.4±4.38% in BMS, p<0.0001). TES demonstrated an inhibitory effect on the smooth muscle cells compared to the other stents. It also suppressed inflammation in the stented lesion compared to SES as evidenced by the inflammation score.
Keywords:polymer;drug-eluting stents;neointimal hyperplasia;percutaneous coronary intervention;restenosis;inflammation
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