Biocompatible Charcoal Composites Prepared by Ionic Liquids for Drug Detoxification

Tae-Joon Park; Patakamuri Govindaiah; Taewon Hwang; Eunkyoung Kim; Sung-Wook Choi; Jung Hyun Kim

Macromolecular Research, Vol.19, No.7, 734-738, July, 2011

DOI10.1007/s13233-011-0713-3 Export Citation

Biocompatible Charcoal Composites Prepared by Ionic Liquids for Drug Detoxification

Tae-Joon Park, Patakamuri Govindaiah, Taewon Hwang, Eunkyoung Kim , Sung-Wook Choi^{1, †}, and Jung Hyun Kim^†

Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 120-749, Korea
¹Department of Biotechnology, The Catholic University of Korea, Gyeonggi, 420-743, Korea

E-mail:,

Cellulose/charcoal and cellulose/heparin/charcoal composites were fabricated using ionic liquids to enhance the biocompatibility of charcoal and decrease the size of their active pores. Surface morphological studies of these biocompatible charcoal composites showed that their uniformly coated surfaces could inhibit the adsorption of proteins while allowing the removal of small drug molecules. The activated partial thromboplastin time demonstrated that heparinized surfaces on the cellulose/heparin/charcoal composite had excellent blood compatibility. These charcoal composites can be useful for the rapid and safe removal of small and hydrophobic drugs from the digestive system of overdose patients by circulating blood in an extracorporeal circuit.

Keywords:activated carbon;ionic liquid;hemoperfusion;blood-compatibility;biocompatibility.

[References]

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Melillo M, Phillips GJ, Davies JG, Lloyd AW, Tennison SR, Kozynchenko OP, Mikhalovsky SV, Carbon, 42, 565 (2004)
Tournier M, Molimard M, Titier K, Cougnard A, Begaud B, Gbikpi-Benissan G, Verdoux H, Psychiat. Res., 152, 73 (2007)
Coffin PO, Tracy M, Bucciarelli A, Ompad D, Vlahov D, Galea S, Acad. Emerg. Med., 14, 616 (2007)
Sherman SG, Cheng YK, Kral AH, Drug. Alcohol. Depen., 88, 182 (2007)
Tan CY, Kim YH, Macromol. Res., 16(6), 481 (2008)
Sather JE, Tantawy H, Anesthesiol. Clin., 24, 647 (2006)
Jeon YS, Son YK, Hong KH, Kim JH, Macromol. Res., 16(4), 379 (2008)
Hickman M, Carrivick S, Paterson S, Hunt N, Zador D, Cusick L, Henry J, Addiction, 102, 317 (2007)
Kim MJ, Kim JH, Yi G, Lim SH, Hong YS, Chung DJ, Macromol. Res., 16(4), 345 (2008)
Prabu P, Kim KW, Dharmaraj N, Park JH, Khil MS, Kim HY, Macromol. Res., 16(4), 303 (2008)
Sarnatskaya VV, Lindup WE, Walther P, Maslenny VN, Yushko LA, Sidorenko AS, Nikolaev AV, Nikolaev VG, Artif. Cell. Blood. Sub., 30, 113 (2002)
Park TJ, Lee SH, Simmons TJ, Martin JG, Mousa SA, Snezhkova EA, Sarnatskaya VV, Nikolaev VG, Linhardt RJ, Chem. Commun., 5022 (2008)
Murugesan S, Mousa S, Vijayaraghavan A, Ajayan PM, Linhardt RJ, J. Biomed. Mater. Res., 79, 298 (2006)
Viswanathan G, Murugesan S, Pushparaj V, Nalamasu O, Ajayan PM, Linhardt RJ, Biomacromolecules, 7(2), 415 (2006)
Park TJ, Weiwer M, Yuan X, Baytas SN, Munoz EM, Murugesan S, Linhardt RJ, Carbohydr. Res., 342, 614 (2007)
Park TJ, Lee MY, Dordick JS, Linhardt RJ, Anal. Biochem., 383, 116 (2008)
Pandey JK, Lee JW, Chu WS, Kim CS, Ahn SH, Lee CS, Macromol. Res., 16(5), 396 (2008)
Brown RM, J. Polym. Sci. A: Polym. Chem., 42(3), 487 (2004)
Fort DA, Remsing RC, Swatloski RP, Moyna P, Moyna G, Rogers RD, Green. Chem., 9, 63 (2007)
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Linhardt RJ, J. Med. Chem., 46, 2551 (2003)
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Murugesan S, Park TJ, Yang HC, Mousa S, Linhardt RJ, Langmuir, 22(8), 3461 (2006)
Kuzniecky R, Murro A, King D, Neurology, 43, 681 (1993)

[Related Articles]

[1] Nakamura T, Oida Y, Matsumoto K, Kawasaki N, Tanada S, J. Environ. Sci. Health Part A-Toxic/Hazard. Subst. Environ. Eng., 37, 905 (2008)

[2] Melillo M, Phillips GJ, Davies JG, Lloyd AW, Tennison SR, Kozynchenko OP, Mikhalovsky SV, Carbon, 42, 565 (2004)

[3] Tournier M, Molimard M, Titier K, Cougnard A, Begaud B, Gbikpi-Benissan G, Verdoux H, Psychiat. Res., 152, 73 (2007)

[4] Coffin PO, Tracy M, Bucciarelli A, Ompad D, Vlahov D, Galea S, Acad. Emerg. Med., 14, 616 (2007)

[5] Sherman SG, Cheng YK, Kral AH, Drug. Alcohol. Depen., 88, 182 (2007)

[6] Tan CY, Kim YH, Macromol. Res., 16(6), 481 (2008)

[7] Sather JE, Tantawy H, Anesthesiol. Clin., 24, 647 (2006)

[8] Jeon YS, Son YK, Hong KH, Kim JH, Macromol. Res., 16(4), 379 (2008)

[9] Hickman M, Carrivick S, Paterson S, Hunt N, Zador D, Cusick L, Henry J, Addiction, 102, 317 (2007)

[10] Kim MJ, Kim JH, Yi G, Lim SH, Hong YS, Chung DJ, Macromol. Res., 16(4), 345 (2008)

[11] Prabu P, Kim KW, Dharmaraj N, Park JH, Khil MS, Kim HY, Macromol. Res., 16(4), 303 (2008)

[12] Sarnatskaya VV, Lindup WE, Walther P, Maslenny VN, Yushko LA, Sidorenko AS, Nikolaev AV, Nikolaev VG, Artif. Cell. Blood. Sub., 30, 113 (2002)

[13] Park TJ, Lee SH, Simmons TJ, Martin JG, Mousa SA, Snezhkova EA, Sarnatskaya VV, Nikolaev VG, Linhardt RJ, Chem. Commun., 5022 (2008)

[14] Murugesan S, Mousa S, Vijayaraghavan A, Ajayan PM, Linhardt RJ, J. Biomed. Mater. Res., 79, 298 (2006)

[15] Viswanathan G, Murugesan S, Pushparaj V, Nalamasu O, Ajayan PM, Linhardt RJ, Biomacromolecules, 7(2), 415 (2006)

[16] Park TJ, Weiwer M, Yuan X, Baytas SN, Munoz EM, Murugesan S, Linhardt RJ, Carbohydr. Res., 342, 614 (2007)

[17] Park TJ, Lee MY, Dordick JS, Linhardt RJ, Anal. Biochem., 383, 116 (2008)

[18] Pandey JK, Lee JW, Chu WS, Kim CS, Ahn SH, Lee CS, Macromol. Res., 16(5), 396 (2008)

[19] Brown RM, J. Polym. Sci. A: Polym. Chem., 42(3), 487 (2004)

[20] Fort DA, Remsing RC, Swatloski RP, Moyna P, Moyna G, Rogers RD, Green. Chem., 9, 63 (2007)

[21] Swatloski RP, Spear SK, Holbrey JD, Rogers RD, J. Am. Chem. Soc., 124(18), 4974 (2002)

[22] Linhardt RJ, J. Med. Chem., 46, 2551 (2003)

[23] Murugesan S, Wiencek JM, Ren RX, Linhardt RJ, Carbohydr. Polym., 63, 268 (2006)

[24] Murugesan S, Park TJ, Yang HC, Mousa S, Linhardt RJ, Langmuir, 22(8), 3461 (2006)

[25] Kuzniecky R, Murro A, King D, Neurology, 43, 681 (1993)